The antidepressant Wellbutrin (bupropion) has been shown to cause birth defects in some children born to mothers taking the drug, according to a study published in the American Journal of Obstetrics & Gynecology on April 26, 2010.

The most common problems are “left outflow tract” heart defects. Left outflow heart defects affect the flow of blood from the heart’s left chambers to the rest of the body. The most common type of left outflow tract heart defect is coarctation of the aorta (CoA), which is a narrowing of the largest artery in the body.

In a study of more than 12,700 infants born in the U.S. between 1997 and 2004, those whose mothers used Wellbutrin (bupropion) during early pregnancy had more than twice the risk of heart defects.

Parents of children suffering from congenital heart defects or other severe congenital malformations may have a cause of action against GlaxoSmithKline (GSK), the manufacturer of Welbutrin, if the mother was prescribed Wellbutrin during pregnancy.

For years, antidepressant drugs like Wellbutrin, Lexapro, Celexa, Prozac, Zoloft and Paxil have been linked to cases of serious congenital heart defects, which may include atrial septal defects (ASD – Hole in the Heart), ventricular septal defects (VSD – Hole in the Heart), tetrology of fallot (ToF), hypoplastic left heart syndrome (HLHS), transposition of the great arteries (TGA or TOGA), patent ductus arteriosus (PDA), total anomalous pulmonary venous return (TAPVR), and coarctation of the aorta (CoA).

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